Biomedis Neogen is a bioresonance device with two feedback modes. Its operation differs from Trinity, which uses a choice of programmed modes.
Two feedback modes
Neogen works through electromagnetic feedback and voice feedback. The manual sets out the sequence and settings for each mode.
Compare Neogen and Trinity
Trinity offers four operating modes, adjustable intensity and PC software updates. Neogen uses the two feedback approaches described above.
Manual and personal guidance
Read the Neogen manual. Contact us with any setup questions.
Biomedis company report: oxidative stress
Biomedis reports a cell-culture study of NEOGEN in electromagnetic feedback mode. The study described below used intestinal, connective-tissue and liver cells.
Trials in Reducing Oxidative Stress
Background
Environmental pollutants such as heavy metals, particulate matter, xenobiotics, pesticides, ultraviolet (UV) radiation, or electromagnetic and geopathic interference fields are well-documented sources or inducers of oxidative stress. Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify these harmful intermediates or repair the resulting damage. This imbalance can cause damage to cells and tissues, contributing to the development of various diseases and health problems.
Research Question
Three different types of cells from connective tissue, intestine, and liver were used to investigate whether the NEOGEN device reduces the amount of ROS present in the culture medium, i.e., in the immediate environment of the cells. The bioassay used here is an animal-free test that is accepted in traditional medicine and international scientific research as one of the main approaches to healthcare.
NEOGEN Device
According to the manufacturer, the NEOGEN device generates modulated electromagnetic signals to "correct natural radiation, enhance, and synchronize the functions of the body and (biological) systems." The NEOGEN device was used only in electromagnetic feedback mode (= Mode 1; EMF F.B.).
Trials in Cell Culture
For this study, the following types of cells were used: (1) intestinal epithelial cells (cell line IPEC-J2); (2) connective tissue fibroblasts (cell line L-929); (3) liver cells (cell line Hep G2). All three cell lines were obtained from the Leibniz Institute, DSMZ, Braunschweig, Germany. Cells were typically cultured in either RPMI 1640 medium or DMEM/Ham F12 medium containing 10% growth mixture and 0.5% gentamicin. The cells were cultured as bulk cultures in an incubator at 37°C in an atmosphere of 5% CO2 and 95% air with approximately 100% humidity.
Experimental Design
Cells were seeded at two cell densities (100,000 cells/well and 50,000 cells/well) in 96-well plates and allowed to adhere and spread for 24 hours. Fresh culture medium containing various concentrations of hydrogen peroxide (= ROS) ranging from 0 (= control) to 3 mM was then added. After 24 hours of ROS exposure, a reaction mixture with fresh culture medium and a water-soluble tetrazolium dye (XTT reagent; Xenometrix, Switzerland) was added to the wells. Changes in the optical density of the dye in the reaction mixture due to cell viability were measured by measuring the difference ∆OD at 450 and 690 nm at specific time points using an Elisareader device (BioTek ELx 808 with Gen 5/3.00 software) and calculated using Microsoft Excel. In all tests, the device was continuously placed on multi-well culture dishes for 24 hours (Figure 1) with 4-6 parallel wells per test and cell type and 4 independent tests (n = 4) with different cell densities.
Results
We observed a concentration-dependent decrease in cell viability caused by the presence of hydrogen peroxide in the culture medium. However, the sensitivity of the three types of cells used varied. Liver cells were the most sensitive cell type, while intestinal cells were the least sensitive. Connective tissue fibroblasts were intermediate between the two. The use of the NEOGEN device resulted in a protective effect for all cell types and cell densities.
Conclusions
The potential of the NEOGEN device to protect against oxidative stress caused by environmental pollutants was demonstrated in this biological cell study. Although different cell types have different baseline sensitivities to reactive oxygen species, the NEOGEN device is capable of reducing undesirable cellular effects by increasing cell viability after oxidative stress exposure.
According to the study results, the NEOGEN device may potentially be useful in several situations related to managing inflammatory processes and oxidative stress. Here are a few examples of situations where the device may be beneficial:
Chronic inflammatory diseases: The device may help reduce oxidative stress and inflammation, which is useful for treating or managing chronic inflammatory diseases such as arthritis, asthma, or inflammatory bowel disease.
Postoperative recovery: Reducing inflammation may promote faster and less painful recovery after surgical interventions.
Pain management: Since reducing inflammation levels can lead to pain reduction, the device can be used for managing chronic pain, such as in osteoarthritis or other painful conditions.
Secondary wound healing: The device may help reduce oxidative stress at the site of inflammation, which can improve the wound healing process.
Sports rehabilitation: For athletes experiencing inflammation and pain after intense training, using such a device may help accelerate recovery and reduce the likelihood of injury.
Read the NEOGEN company report.